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  1. Home/
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  3. MLB/
  4. Sox vs Astros

Chicago White Sox vs Houston AstrosMLB Picks, Prediction & Odds • Sep 29 • 05:00 PM

Chicago White Sox logo

Sox

0-0
Starting Now
Houston Astros logo

Astros

4Picks

Experts Betting This Game

4 experts have a pick on Sox vs Astros

View Expert Picks
Felipe Brown

Felipe Brown

70% Win Rate
Pick on this game
Premium pick +100Unlock
Frankie the Fan

Frankie the Fan

70% Win Rate
Pick on this game
Premium pick +100Unlock
Felipe Brown

Felipe Brown

70% Win Rate
Pick on this game
Premium pick +100Unlock
Frankie the Fan

Frankie the Fan

70% Win Rate
Pick on this game
Premium pick +100Unlock
Preview · 15s

Our Prediction

Free Pick
Chicago White Sox logoSox49%
51%AstrosHouston Astros logo
Chicago White Sox logo
Sox
VS
Houston Astros logo
Astros5
Confidence
Medium

We predict Houston Astros to win 5-3

Key Factors

Betting Odds

Betting odds imply a 53% chance for Sox

Head-to-Head

Astros leads the recent series 5-2

Chicago White Sox vs Houston Astros MLB Preview – September 29, 2026

Chicago White Sox vs Houston Astros — MLB featured preview

Head-to-Head

Last 7 meetings

Chicago White Sox logo
2
Sox
Houston Astros logo
5
Astros
29%
71%

Recent Matchups

Jul 24, 2026
5-9
Astros
Jul 25, 2026
1-4
Astros
Jul 26, 2026
12-3
Sox
Aug 31, 2026
3-6
Astros
Sep 1, 2026
5-1
Sox

H2H Averages (Last 3 Games)

6.0
5.3
Sox AvgAvg ScoreAstros Avg
4

Expert Picks Available

Professional handicappers have analyzed this game

Betting Odds

Chicago White Sox logoSox
AstrosHouston Astros logo
Spread
-1.50
+155
1.50
-189
Moneyline
-125
FAV
+105
Total (O/U 8.00)
Over
-115
Under
-105

Recent Matchups

9/3/20260 - 2

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Frequently asked questions

Who is favored to win Chicago White Sox vs Houston Astros?▾

Chicago White Sox are favored over Houston Astros based on the latest moneyline (Sox -125, Astros +105).

What is the point spread for Chicago White Sox vs Houston Astros?▾

Sox -1.50, Astros 1.50. Spread reflects the projected margin between the two teams.

What is the over/under for Chicago White Sox vs Houston Astros?▾

The total (over/under) is 8.00. Over 8.00 or under 8.00 wins respectively.

When is Chicago White Sox vs Houston Astros?▾

Chicago White Sox vs Houston Astros is scheduled for Sep 29 at 05:00 PM ET.

More MLB picks

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    Tue, Sep 29
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    Sun, Sep 27
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    Sun, Sep 27
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    Sun, Sep 27
See all MLB picks →
4

Expert Picks Available

Professional handicappers have analyzed this game

Betting Odds

Chicago White Sox logoSox
AstrosHouston Astros logo
Spread
-1.50
+155
1.50
-189
Moneyline
-125
FAV
+105
Total (O/U 8.00)
Over
-115
Under
-105
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SportsHub may earn a commission from sportsbook partners linked from this site. Picks and editorial content are produced independently of any partnership. Affiliate Disclosure

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