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  1. Home/
  2. Picks/
  3. MLB/
  4. Sox vs Guardians

Boston Red Sox vs Cleveland GuardiansMLB Picks, Prediction & Odds β€’ Sep 22 β€’ 06:46 PM

Boston Red Sox logo

Sox

0-0
Starting Now
Cleveland Guardians logo

Guardians

2Picks

Experts Betting This Game

2 experts have a pick on Sox vs Guardians

View Expert Picks
Kyle Hunter

Kyle Hunter

70% Win Rate
Pick on this game
Premium pick +100Unlock
Hunter Price

Hunter Price

70% Win Rate
Pick on this game
Premium pick +100Unlock
Kyle Hunter

Kyle Hunter

70% Win Rate
Pick on this game
Premium pick +100Unlock
Hunter Price

Hunter Price

70% Win Rate
Pick on this game
Premium pick +100Unlock

Our Prediction

Boston Red Sox logoSox55%
45%GuardiansCleveland Guardians logo
Boston Red Sox logo
Sox
84-72American League #3
VS
Cleveland Guardians logo
Guardians
81-75American League #4
Confidence
Low

We predict Boston Red Sox

Key Factors

Betting Odds

Betting odds imply a 54% chance for Sox

Season Record

Sox is 84-72 this season

Standings Position

Sox ranked #3 in standings

Head-to-Head

Sox leads the recent series 2-1

Team Comparison

Boston Red Sox logoSox
GuardiansCleveland Guardians logo
84-72
Record
81-75
53.8%
Win %
51.9%
#3
Ranking
#4

Head-to-Head

Last 3 meetings

Boston Red Sox logo
2
Sox
Cleveland Guardians logo
1
Guardians
67%
33%

Recent Matchups

May 29, 2026
3-4
Guardians
May 30, 2026
9-1
Sox
May 31, 2026
9-4
Sox

H2H Averages (Last 3 Games)

7.0
3.0
Sox AvgAvg ScoreGuardians Avg
2

Expert Picks Available

Professional handicappers have analyzed this game

Betting Odds

Boston Red Sox logoSox
GuardiansCleveland Guardians logo
Spread
-1.50
+168
1.50
-204
Moneyline
-132
FAV
+108
Total (O/U 6.50)
Over
-123
Under
+102

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Frequently asked questions

Who is favored to win Boston Red Sox vs Cleveland Guardians?β–Ύ

Boston Red Sox are favored over Cleveland Guardians based on the latest moneyline (Sox -132, Guardians +108).

What is the point spread for Boston Red Sox vs Cleveland Guardians?β–Ύ

Sox -1.50, Guardians 1.50. Spread reflects the projected margin between the two teams.

What is the over/under for Boston Red Sox vs Cleveland Guardians?β–Ύ

The total (over/under) is 6.50. Over 6.50 or under 6.50 wins respectively.

When is Boston Red Sox vs Cleveland Guardians?β–Ύ

Boston Red Sox vs Cleveland Guardians is scheduled for Sep 22 at 06:46 PM ET.

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See all MLB picks β†’
2

Expert Picks Available

Professional handicappers have analyzed this game

Betting Odds

Boston Red Sox logoSox
GuardiansCleveland Guardians logo
Spread
-1.50
+168
1.50
-204
Moneyline
-132
FAV
+108
Total (O/U 6.50)
Over
-123
Under
+102
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