Buffalo Bills vs Detroit LionsNFL Picks, Prediction & Odds • Sep 17 • 08:00 PM

Buffalo Bills are favored over Detroit Lions based on the latest moneyline (Bills -227, Lions +189).

Bills -4.50, Lions 4.50. Spread reflects the projected margin between the two teams.

The total (over/under) is 53.50. Over 53.50 or under 53.50 wins respectively.

Buffalo Bills vs Detroit Lions is scheduled for Sep 17 at 08:00 PM ET.