The NFL season is in full swing, and Week 4 is shaping up to be a crucial juncture for several teams vying for early-season momentum. As the dust settles on the opening games, fans and analysts alike focus on the standout matchups that promise high stakes and thrilling action. From teams seeking redemption to those aiming to establish dominance, the narratives heading into Week 4 are rich with intrigue and potential drama.
Must-Watch Matchups and High-Stakes Showdowns
Among the most anticipated games is Thursday Night Football, as the Seattle Seahawks visit the Arizona Cardinals. Both clubs are retooling after injury-plagued starts, and Seattle’s offense—led by Geno Smith—will need to click against an Arizona secondary still finding its footing under new coordinator Sean Desai. On Sunday, the Tennessee Titans travel to face the Houston Texans in a pivotal AFC South showdown. Rookie sensation C.J. Stroud looks to build on his strong start against a Titans defense featuring fresh faces like Kevin Byard. Finally, perhaps the marquee matchup of the weekend is Baltimore Ravens at Kansas City Chiefs. Lamar Jackson and Patrick Mahomes square off once again in what promises to be an offensive clinic at Arrowhead Stadium; if either team wants to stake an early claim in the AFC race, this game could go a long way toward determining who takes over the division.
Get Locked In With Our Week 4 NFL Picks
A lot is happening in the NFL right now. Injuries are beginning to play a larger role for some clubs, while others are still ironing out coaching kinks and roster rotations. Our expert team at SportsHub.com has boots on the ground at many venues nationwide. For most recreational bettors, staying current with every piece of news is impossible—and that’s why we’re here for you.
Find the news and notes you want, or tail some of our professional handicappers and get on the winning side. Check out our leaderboard to see which handicappers are trending: SportsHub Leaderboard. Then dive into proven strategies at our Blog Strategies page to refine your approach.
SportsHub: Free Week 4 NFL Picks and Our Exclusive Offerings
Each week, we provide a variety of complimentary NFL picks designed to help you make informed and strategic decisions throughout the season. Our experts carefully analyze our selections, leveraging the latest data, trends, and insider insights. Here are some of the categories we cover:
• Best Pick Against the Spread (ATS): Our ATS pick highlights the best wager for teams expected to cover the point spread, providing valuable insight into matchups with the most potential.
• Best Moneyline Pick: For those who prefer betting on outright winners, our moneyline pick offers a top selection based on a comprehensive analysis of team performance, player statistics, and other critical factors.
• Best Total Pick: Our total pick focuses on the over/under, helping you identify games where total points will likely go over or under the set line.
• Best Player Prop: Dive into individual player performances with our best player prop pick. Whether it’s passing yards, touchdowns, or receptions, we pinpoint standout player prop bets that offer excellent value.
• Best Team Prop: Explore team-centric bets with our best team prop pick. These can include total team points, turnovers, or specific team milestones, providing a broader range of betting opportunities.
For bettors looking to make real-time decisions, check out our Live Betting Handbook to capitalize on in-game angles. If you prefer proven recommendations, browse our Service Plays and specifically our Football Service Plays for expert-curated picks.
Our commitment is to deliver high-quality, reliable picks every week, backed by rigorous research and expert analysis. Stay tuned for our NFL Week 4 predictions and elevate your betting strategy with our top-tier insights.
Top Week 4 NFL Storylines
Week 4 of the NFL season is packed with matchups critical for division races and team momentum. From the Seahawks–Cardinals Thursday night clash to the Titans–Texans AFC South battle, and the primetime showdown between the Ravens and Chiefs, these games are set to deliver drama, excitement, and pivotal moments. Don’t miss out on the action as these teams compete on the road to the playoffs.
Win Together With Our Week 4 NFL Picks
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Week 4 NFL Schedule (2025)
| Date | Time (ET) | Away Team | Home Team | Stadium |
|---|---|---|---|---|
| Thu, Sept 25 | 8:15 PM | Seattle Seahawks | Arizona Cardinals | State Farm Stadium |
| Sun, Sept 28 | 9:30 AM | Minnesota Vikings | Pittsburgh Steelers (Dublin) | Croke Park, Dublin |
| Sun, Sept 28 | 1:00 PM | Washington Commanders | Atlanta Falcons | Mercedes-Benz Stadium |
| Sun, Sept 28 | 1:00 PM | New Orleans Saints | Buffalo Bills | Highmark Stadium |
| Sun, Sept 28 | 1:00 PM | Cleveland Browns | Detroit Lions | Ford Field |
| Sun, Sept 28 | 1:00 PM | Tennessee Titans | Houston Texans | NRG Stadium |
| Sun, Sept 28 | 1:00 PM | Carolina Panthers | New England Patriots | Gillette Stadium |
| Sun, Sept 28 | 1:00 PM | Los Angeles Chargers | New York Giants | MetLife Stadium |
| Sun, Sept 28 | 1:00 PM | Philadelphia Eagles | Tampa Bay Buccaneers | Raymond James Stadium |
| Sun, Sept 28 | 4:05 PM | Indianapolis Colts | Los Angeles Rams | SoFi Stadium |
| Sun, Sept 28 | 4:05 PM | Jacksonville Jaguars | San Francisco 49ers | Levi’s Stadium |
| Sun, Sept 28 | 4:25 PM | Baltimore Ravens | Kansas City Chiefs | GEHA Field at Arrowhead |
| Sun, Sept 28 | 4:25 PM | Chicago Bears | Las Vegas Raiders | Allegiant Stadium |
| Sun, Sept 28 | 8:20 PM | Green Bay Packers | Dallas Cowboys | AT&T Stadium |
| Mon, Sept 29 | 7:15 PM | New York Jets | Miami Dolphins | Hard Rock Stadium |
| Mon, Sept 29 | 8:15 PM | Cincinnati Bengals | Denver Broncos | Empower Field at Mile High |