NFL Week 2 Picks for 2025
The 2025 NFL season is off to a fast start, and Week 2 promises even more high-stakes action. With several showcase matchups—highlighted by Thursday Night Football, a feature-filled Sunday slate and a Monday night finale—bettors will find ample opportunities to identify value. No team wants to begin the season 0–2, so expect sharp bettors to exploit lingering market inefficiencies after Week 1. Below, we break down the top storylines, underdog trends, betting concepts and expert insights to inform your Week 2 picks.
Finding Value in Underdogs
Last season’s Week 2 saw seven underdogs win outright, rewarding those who looked past the lines. In Week 2 of 2024, underdogs went 7–8 straight up (SU), with notable upsets including the Buffalo Bills as 2.5-point underdogs at Miami, and the Arizona Cardinals knocking off the Las Vegas Raiders despite a double-digit line. Week 2 often presents challenges for oddsmakers: they sometimes overreact—or underreact—to Week 1 results, and certain offensive or defensive weaknesses can be exploited before markets adjust. Understanding which teams underperformed out of the gate, or which lines reflect an over/underreaction, can offer significant profit potential early in the season.
Expert handicappers spend extra hours dissecting film and identifying where early-season lines misprice Week 2 matchups. For foundational betting concepts, see How to Bet on Football. For deeper strategy, refer to NFL Betting Strategies That Will Bring Profits in 2025, where professionals detail how to leverage market adjustments and identify sharp edges in the first few weeks of the season.
What to Expect from the 2025 NFL Season
Week 2 features matchups that could define divisional races and playoff paths:
- Thursday Night Football: The Washington Commanders visit the Green Bay Packers at Lambeau Field (7:15 PM CT, Prime Video). Both teams pulled off key wins in Week 1—Washington on the road and Green Bay with a convincing home victory—so this prime-time spotlight should be competitive.
- Sunday Headlines: Key AFC contests include the Baltimore Ravens hosting the Cleveland Browns (1:00 PM ET, CBS) and the Cincinnati Bengals facing the Jacksonville Jaguars (1:00 PM ET, CBS), both heavy early divisional tests. In the NFC, the Atlanta Falcons travel to the Carolina Panthers (1:00 PM ET, FOX), and the San Francisco 49ers host the Arizona Cardinals (4:25 PM ET, FOX). The Dallas Cowboys at Chicago Bears (4:25 PM ET, FOX) game features two offenses capable of explosive plays.
- Sunday Night Football: The Kansas City Chiefs head to the New York Giants (8:20 PM ET, NBC). Both franchises are aiming to prove early that they can sustain title-contending form; this late-slot game should have playoff implications.
- Monday Night Football: The Detroit Lions visit the Baltimore Ravens (8:15 PM ET, ESPN/ABC). After a thrilling Week 1, both teams will look to carry momentum forward.
Across the board, bettors will want to monitor injury reports (particularly for QBs), watch how each coaching staff responds in Week 2, and identify where lines may lag after Week 1 results.
Best NFL Week 2 Picks – Top Football Betting Markets
At SportsHub, we’ll offer top plays for the most popular Week 2 markets. Our NFL experts have combined their film study, analytics and insider intel to present:
- Best pick against the spread
- Best moneyline pick
- Best total bet (OVER/UNDER)
- Best player prop
- Best team prop
Expect our selections to leverage both statistical models and experienced handicapping insights. If you want to access the sharpest plays—unique breakdowns, play-by-play tendencies and sideline intel—check out our Football Service Plays. To learn about all the benefits of membership, see Sports Hub – What We Have To Offer.
Week 2 is the pivotal point where early lines can be most vulnerable. Between film adjustments, emerging injuries and coaching schemes settling, the data edge is with those who dig deeper. For why purchasing expert picks can pay dividends, review our Handicapper Leaderboard.
Boost Your Game Plan with Week 2 Insights from SportsHub Experts
Start Week 2 armed with cutting-edge strategies from the SportsHub team. Follow us on Instagram @sports_hub_com and Twitter @sportshub_com. Don’t miss our video breakdowns and detailed previews on YouTube, where we dive into film, point-spread movements and player performance metrics.
Our commitment is to provide you the most precise forecasts, backed by leading-edge sports analytics. We conduct thorough research on every matchup so you have the critical information exactly when you need it. Whether you’re a casual bettor or a seasoned pro, our Week 2 coverage is designed to keep you ahead of the game.
We appreciate your feedback—please let us know how we can improve, and enjoy the Week 2 slate. Good luck and bet responsibly.
Week 2 Schedule (Regular Season)
| Date | Time (ET) | Away Team | Home Team | Network |
|---|---|---|---|---|
| Thu, Sep 11, 2025 | 7:15 PM CT / 8:15 PM ET | Washington Commanders | Green Bay Packers | Prime Video |
| Sun, Sep 14, 2025 | 1:00 PM ET | Atlanta Falcons | Carolina Panthers | FOX |
| Sun, Sep 14, 2025 | 1:00 PM ET | Baltimore Ravens | Cleveland Browns | CBS |
| Sun, Sep 14, 2025 | 1:00 PM ET | Cincinnati Bengals | Jacksonville Jaguars | CBS |
| Sun, Sep 14, 2025 | 1:00 PM ET | Houston Texans | Miami Dolphins | CBS |
| Sun, Sep 14, 2025 | 4:25 PM ET | Dallas Cowboys | Chicago Bears | FOX |
| Sun, Sep 14, 2025 | 4:25 PM ET | Arizona Cardinals | San Francisco 49ers | FOX |
| Sun, Sep 14, 2025 | 8:20 PM ET | Kansas City Chiefs | New York Giants | NBC |
| Mon, Sep 15, 2025 | 8:15 PM ET | Detroit Lions | Baltimore Ravens | ESPN/ABC |