Week 12 NFL Picks and Predictions: Thanksgiving Football and Divisional Drama

Week 12 is here—and with it comes some of the most anticipated football action of the season. From Thursday Night Football to a full Sunday slate loaded with divisional matchups, there’s no shortage of betting angles and key storylines to monitor. Whether you’re eyeing primetime value or looking to capitalize on late-season divisional stakes, our Week 12 NFL picks have you covered.

Thursday Night Football Primetime Showdown

Buffalo at Houston ( 8:15 p.m. ET, Prime Video)
The Buffalo Bills head to NRG Stadium to face the Houston Texans on Thursday Night Football. The Bills boast a perfect TNF record under Josh Allen, going 7–0 in previous appearances. Buffalo’s high-powered offense, led by Allen, will test Houston’s improved defense—particularly after the Texans’ offseason additions such as C.J. Gardner-Johnson and Christian Kirk. Early lines have Buffalo favored by around 3½ points, but Houston’s home-field edge and prime-time environment could keep this closer than expected.

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Week 12 NFL Picks: Sunday Showdowns

Sunday’s slate features a slew of divisional battles and marquee matchups that will shape playoff seeding. Here are a few key games we’re eyeing:

Patriots at Bengals ( 1 p.m. ET, CBS)
New England visits Cincinnati in a clash that could determine the AFC East pecking order. The Bengals, fresh off a bye, aim to avenge last year’s divisional slip-up. With Joe Burrow operating at elite efficiency and the Patriots relying on a balanced attack, expect a competitive, low-scoring affair. Cincinnati opened as a 5½-point favorite, but New England’s opportunistic defense has a knack for forcing turnovers.

Steelers at Bears ( 1 p.m. ET, CBS)
Pittsburgh’s defense has been dominant, yet Chicago’s offense features weapons like Justin Fields and D.J. Moore. The Bears have struggled to find consistency, but playing at home could inspire an upset. Early projections split this one nearly even, with Chicago installed as a 1-point underdog. Look for the Steelers’ rush defense to be the deciding factor.

Colts at Chiefs ( 1 p.m. ET, CBS)
Indianapolis travels to Arrowhead for what could be a statement game for both clubs. The Chiefs, while not the same juggernaut of recent years, still punish opponents with their firepower. The Colts have performed well under pressure, but Kansas City’s home crowd and Mahomes in prime form make them a strong pick to cover as a 7-point favorite.

Jets at Ravens ( 1 p.m. ET, CBS)
New York’s rugged defense will face one of the league’s top rushing attacks led by Lamar Jackson. Early action has Baltimore as a 4-point favorite at home, but with the Jets’ “D” forcing turnovers, an upset remains plausible.

Giants at Lions ( 1 p.m. ET, Fox)
Big Blue travels to Detroit for a local rivalry tilt. The Lions have been surging under Dan Campbell, and with home-field advantage, they enter as 6-point favorites. The Giants’ inconsistent offense will struggle to keep pace unless Saquon Barkley breaks loose for big plays.

Seahawks at Titans ( 1 p.m. ET, Fox)
Seattle’s secondary, one of the best in the league, will aim to contain Derrick Henry. The Titans have suffered injuries on offense, making them a 3-point home underdog. If the Seahawks’ offense (led by Geno Smith) can avoid turnovers, they should cover easily.

Vikings at Packers ( 1 p.m. ET, Fox)
A crucial NFC North showdown. Minnesota visits Lambeau Field looking to solidify its divisional lead. Early odds have the Packers as 2½-point home underdogs despite the crowd noise advantage. With both teams excelling defensively, this one could come down to the final possession.

Browns at Raiders ( 4:05 p.m. ET, CBS)
Cleveland fights to keep pace in the AFC North, while Las Vegas aims to snap a late-season slump. The Browns opened as 2-point road favorites—look for Deshaun Watson’s mobility to tilt this toward Cleveland if he stays healthy.

Jaguars at Cardinals ( 4:05 p.m. ET, CBS)
Jacksonville’s aerial attack (led by Trevor Lawrence) meets Arizona’s rebuilding offense. Early lines have the Jaguars as 4-point favorites; if Jags’ defense continues to improve, they should cruise.

Falcons at Saints ( 4:25 p.m. ET, Fox)
Atlanta looks to keep momentum against a New Orleans team that struggles offensively. The Falcons opened as a 3-point road favorite in the Dome. If Desmond Ridder protects the ball, this is a solid cover pick.

Eagles at Cowboys ( 4:25 p.m. ET, Fox)
Philly travels to Jerry World in a late-afternoon prime matchup. The Cowboys, despite a disappointing start, have rebounded under Mike McCarthy. Early odds have Dallas as a 2-point favorite—consider backing Philly on the spread if Jalen Hurts and the Eagles’ defense click.

Buccaneers at Rams ( 8:20 p.m. ET, NBC)
Tampa Bay reaches Hollywood for a Sunday night tilt. Tampa’s offense has sputtered at times, while the Rams have struggled to find consistency in Sean McVay’s offense. Early lines split this one evenly; if Tampa’s run game (led by Rachaad White) gains traction, they could steal a win in SoFi Stadium.

Week 12 NFL Spreads to Watch

Looking to narrow your focus? These matchups stand out based on line movement, matchups, and momentum heading into the weekend:

• Bills at Texans (TNF): Buffalo opened as a 3½-point favorite, but some early sharp money on Houston has pushed the line down to 3. With the “D” in Houston playing better than expected, keep an eye on any further drop.
• Patriots at Bengals: Cincinnati is currently a 5½-point favorite, but New England’s recent upsets have caused some bettors to back the Pats. Monitor any shift toward the underdog here.
• Steelers at Bears: Steelers installed as 2-point favorites in Chicago. If the Bears’ home crowd factor remains strong, look for this line to fluctuate around the pick-’em mark.
• Colts at Chiefs: Kansas City opened as a 7-point favorite, but early Colts backers have driven it to 6½. Keep tabs on Kansas City’s injury report—any key absences could spark more line movement.
• Giants at Lions: Detroit is a 6-point favorite at home. With the Lions on a three–game win streak, look for this line to tick up toward 6½ or 7 if early bets flood in.
• Vikings at Packers: Minnesota as a 2½-point favorite in Lambeau. If the Packers’ crowd noise is as loud as expected, the line might dip closer to 2.
• Eagles at Cowboys: Dallas holds a 2-point home edge. With playoff implications brewing, sharp bettors may move this toward a pick-’em. Watch movement closely.
• Buccaneers at Rams: Currently even money. If Tampa’s running game continues to find lanes, this line could shift in their favor.

Revamp Your NFL Game Plan with SportsHub

The regular season is entering its final push, and that means every point, every play, and every bet matters more. At SportsHub, our experts are analyzing matchups, coaching trends, and player performance data to help you stay ahead of the curve.

Need help refining your fundamentals? The Bettors Handbook walks through strategies for spread betting, bankroll discipline, and spotting sharp angles—especially useful during tightly lined divisional weeks like this.

For deeper insights on advanced wagering tactics, check out our Strategies Blog.

If you’re looking for trusted platforms to make your plays, our Service Plays guide compares performance, pricing, and reliability across the industry. Football-specific recommendations can be found on our Football Service Plays page.

Week 12 is going to deliver primetime fireworks and late-season drama. Whether you’re betting sides, totals, or locking in mid-week value, we’re here to help you make smarter decisions. So tune in, fire up the app, and get ready for a weekend of football fever.

Week 12 Schedule

Day	Date	Time (ET)	Matchup	Network
Thursday	Nov. 20, 2025	8:15 p.m.	Buffalo Bills at Houston Texans	Prime Video
Sunday	Nov. 23, 2025	1 p.m.	New England Patriots at Cincinnati Bengals	CBS
Sunday	Nov. 23, 2025	1 p.m.	Pittsburgh Steelers at Chicago Bears	CBS
Sunday	Nov. 23, 2025	1 p.m.	Indianapolis Colts at Kansas City Chiefs	CBS
Sunday	Nov. 23, 2025	1 p.m.	New York Jets at Baltimore Ravens	CBS
Sunday	Nov. 23, 2025	1 p.m.	New York Giants at Detroit Lions	Fox
Sunday	Nov. 23, 2025	1 p.m.	Seattle Seahawks at Tennessee Titans	Fox
Sunday	Nov. 23, 2025	1 p.m.	Minnesota Vikings at Green Bay Packers	Fox
Sunday	Nov. 23, 2025	4:05 p.m.	Cleveland Browns at Las Vegas Raiders	CBS
Sunday	Nov. 23, 2025	4:05 p.m.	Jacksonville Jaguars at Arizona Cardinals	CBS
Sunday	Nov. 23, 2025	4:25 p.m.	Atlanta Falcons at New Orleans Saints	Fox
Sunday	Nov. 23, 2025	4:25 p.m.	Philadelphia Eagles at Dallas Cowboys	Fox
Sunday	Nov. 23, 2025	8:20 p.m.	Tampa Bay Buccaneers at Los Angeles Rams	NBC
Monday	Nov. 24, 2025	8:15 p.m.	Carolina Panthers at San Francisco 49ers	ESPN

Bye Weeks: Denver Broncos, Los Angeles Chargers, Miami Dolphins, Washington Commanders